Protein Details: Glutamate receptor ionotropic; kainate glr-3

Protein ID

ICDB_Pro_0867

Protein Name

Glutamate receptor ionotropic; kainate glr-3

Gene Name

glr-3; K10D3.1

Organism

Caenorhabditis elegans

Length

836 amino acids

AlphaFoldDB

AF-Q21415-F1-model_v4.pdb

Function

Ionotropic glutamate receptor (By similarity). Activation by glutamate requires additional verification. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change; leading to the opening of the cation channel; and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state; characterized by the presence of bound agonist (By similarity). Independent of its ionotropic glutamate receptor activity; acts as a thermoreceptor in the ASER neuron where it triggers a calcium response to activate cold avoidance behavior in response to temperatures below 19 degrees Celsius. Possibly functions as a metabotropic cold receptor and acts upstream of the G(o) G protein goa-1 in the ASER neuron. Also functions in cold sensing in the intestine.

Sequence

MFWIAKTLIAFLILLKTDCYKIAIPANLIDEVNPVLEFVDFRVQVIPYETKPLWRIKQESFKIVGISIENGLFSVCNCLILGASAIILPEQYDGHLAAAAIVQSIADNTNVPCVSLHLSPPTRPSTHLHPHLNAKSLAVAAFIKREKWKDVVVVFEEPDELLEITDMITAGHFDPDSFSSQLVRLKHGDDYGNELKHIKNKLDRYRIVINIPLQKALHFLEQAANMSMCGVLYHYVVMDMDLVTVDIDSIRGIEDCNITSFGVHDVNSEYIEDIRQEIVHKSSIRLPKKGVPYTTSIWIDTLRLLIRSMKSIQIWDEPRCGSSWKSGSDIKKRFFENPLAGISGDLHWAPSGERSNYTLHVYRRTLSFQKFAEWSSRTRRIASSEAVVIANSSEKLTLEGKHLKISVYLEAPFVMITSNGSYEGYCIDLLHKIANILKFTYTIQKVRDNAYGSKESNGKWSGMVGELQRGDADLAVASLTISYGRSEVIDFTVPYMHLGISILFKKPRIRDSDWFKFMDPLSTQVWIMTFASYFVVSVAIWIIAKISPYEQFERDEDNGQYKPVDNQFSLRNSFWFTVCSLMQQGSELCPRAASTRLLTGIWWFFALILISSYTANLAAVLTTRRMETPIENADDLAAQTKIKYGTLGRGSTMSFFNESKIETYERMWQLMSSSPGLFVQSSKEGIARVKSSDYAYLMESSMLEYAVERDCELMQIGGLIDQKGYGIGLPKGSPYRELISTAILRLQEKTELTELKEKWWKDKSVVCEQPKRKDQDDGESIGGIFIILVVGLVLTAVLVIFELITTRKPSPAQSQVIRHVNVIPSFKLGFFRWNVN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 478..480; /ligand="L-glutamate"; BINDING 485; /ligand="L-glutamate"; BINDING 651..652; /ligand="L-glutamate"; BINDING 699; /ligand="L-glutamate"

Disease

Location

Expressed in the intestine and in the ASER neuron (PubMed:31474366). Also expressed in the thermosensitive RIA interneuron (PubMed:11222641).

DOI ID

10.1126/science.282.5396.2012; 10.1523/jneurosci.21-05-01510.2001; 10.1016/j.cell.2019.07.034

RefSeq

NP_492017.3